Open AccessGadolinium‐induced nephrotoxicity
Author(s) -
Buhaescu I.,
Izzedine H.
Publication year - 2008
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2007.01582.x
Subject(s) - medicine , nephrotoxicity , renal function , gadolinium , iodinated contrast , kidney disease , nephrogenic systemic fibrosis , nephrology , magnetic resonance imaging , iodinated contrast media , nephropathy , radiology , urology , kidney , endocrinology , diabetes mellitus , computed tomography , materials science , metallurgy
Summary Because of the well‐documented risk of acute renal failure with the iodinated contrast media in patients with underlying chronic renal insufficiency, the use of intravenous gadolinium‐based contrast media in magnetic resonance imaging for diagnostic and interventional radiology procedures has become a well‐established clinical practice in the recent years. Although originally thought to be safe and lack the nephrotoxic effects of iodinated contrast media, gadolinium‐based contrast media have recently been reported to induce a usually reversible decrease of glomerular filtration rate in a high‐risk population group, especially in patients with altered baseline renal function. Here we present the current experimental and clinical evidence on this new challenge for the nephrologist, gadolinium‐induced nephrotoxicity in patients with chronic kidney disease.