Open AccessLipoprotein(a) levels in patients with unstable angina and their relationship with atherothrombosis and myocardial damage
Author(s) -
Yazici M.,
Demircan S.,
Durna K.,
Sahin M.
Publication year - 2005
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2005.00442.x
Subject(s) - medicine , lipoprotein(a) , unstable angina , fibrinogen , cardiology , lipoprotein , angina , coagulation , myocardial infarction , cholesterol
Summary The aim of the study was to compare lipoprotein(a) [Lp(a)] levels in patients with cTroponin‐I (cTn‐I)‐positive or ‐negative unstable angina and to investigate their relationship with atherothrombosis. A total of 202 consecutive patients were enrolled in the study. Lp(a), fibrinogen, plasminogen, PAI‐1 and t‐PA levels were measured and C‐reactive protein (CRP) assays were performed on admission for all patients, and venous blood samples were drawn 12 and 24 h later for cTn‐I measurements. The patients were divided into cTn‐I‐negative (cTn‐I < 1 ng/ml) and ‐positive (cTn‐I ≥ 1 ng/ml) unstable angina groups. Lp(a) levels of the cTn‐I‐positive patients were higher than those of the cTn‐I‐negative patients (52.9 ± 6.0 and 15.7 ± 2.5 mg/dl, p < 0.0001). There was a positive correlation between Lp(a) and cTn‐I levels ( r = 0.692; p = 0.0001). Increase in coagulation activity and impairment in fibrinolytic activity were significant in the cTn‐I‐positive patients. Elevated Lp(a) levels may have a role in the development of myocardial damage in patients with unstable angina.