Open AccessLevels of serum vitamin A, alpha‐tocopherol and malondialdehyde in patients with non‐alcoholic steatohepatitis: relationship with histopathologic severity
Author(s) -
Bahcecioglu I.H.,
Yalniz M.,
Ilhan N.,
Ataseven H.,
Ozercan I.H.
Publication year - 2005
Publication title -
international journal of clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 98
eISSN - 1742-1241
pISSN - 1368-5031
DOI - 10.1111/j.1742-1241.2004.00312.x
Subject(s) - steatohepatitis , medicine , malondialdehyde , alpha tocopherol , vitamin e , tocopherol , gastroenterology , fatty liver , alpha (finance) , vitamin , surgery , oxidative stress , antioxidant , biochemistry , disease , chemistry , construct validity , patient satisfaction
Summary The aims of our study were to estimate serum levels of malondialdehyde (MDA), serum levels of vitamin A and alpha‐tocopherol as antioxidants and determine relationship of these with histopathologic severity in patients with non‐alcoholic steatohepatitis (NASH). Twenty‐nine patients with biopsy‐proven NASH were included to study. NASH were histopathologically scored for grading and staging. Serum MDA and vitamin A levels were increased in patients with NASH and simple steatosis as compared to healthy control group. Serum alpha‐tocopherol levels measured in simple steatosis and NASH were significantly lower than in healthy control group There was no significant difference between grade/stage 0–1 and grade/stage 2–3 in terms of MDA, vitamin A and alpha‐tocopherol levels. Serum MDA and vitamin A levels are increased in simple steatosis and NASH. MDA, vitamin A and alpha‐tocopherol levels in NASH were not associated with the histopathologic severity.