Premium
Vitamin D deficiency and secondary hyperparathyroidism in older people with low trauma fractures
Author(s) -
Hii Susanna,
Scherer Sam
Publication year - 2004
Publication title -
australasian journal on ageing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.63
H-Index - 34
eISSN - 1741-6612
pISSN - 1440-6381
DOI - 10.1111/j.1741-6612.2004.00011.x
Subject(s) - medicine , vitamin d deficiency , secondary hyperparathyroidism , hyperparathyroidism , parathyroid hormone , vitamin d and neurology , creatinine , cohort , anthropometry , endocrinology , pediatrics , calcium
Objectives: To determine the prevalence of vitamin D deficiency and hyperparathyroidism in older patients with low trauma fractures, and to develop a statistical model to predict the serum level of 25‐hydroxyvitamin D required to prevent secondary hyperparathyroidism.Method: Descriptive cohort study conducted in an aged care centre in Melbourne, Australia. Participants comprised 107 patients aged over 65 years with low trauma fractures. Serum 25‐hydroxyvitamin D (25OHD), parathyroid hormone (PTH) and plasma creatinine levels were measured. Anthropometric data, Barthel index, Mini‐Mental State Examination and use of diuretics were also assessed.Results: Fifty‐one per cent of patients had 25OHD <30 nmol/L and 86% had 25OHD <50 nmol/L. Thirty‐two per cent had secondary hyperparathyroidism which was significantly associated with vitamin D deficiency and use of frusemide. Statistical models demonstrated higher PTH at serum 25OHD below 60 nmol/L.Conclusions: Vitamin D deficiency is common among older people. Serum 25OHD may need to be greater than 60 nmol/L to prevent secondary hyperparathyroidism.