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Alzheimer's Disease and Brain Reserve
Author(s) -
Schofield Peter
Publication year - 1999
Publication title -
australasian journal on ageing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.63
H-Index - 34
eISSN - 1741-6612
pISSN - 1440-6381
DOI - 10.1111/j.1741-6612.1999.tb00081.x
Subject(s) - cognitive reserve , disease , pathological , alzheimer's disease , neuroscience , psychology , medicine , dementia , pathology
. Alzheimer's disease has a long early phase in which limited pathological changes accumulate without apparent functional consequences. Once pathology exceeds a certain threshold, clinical features arise, but this threshold seems to differ from patient to patient, reflecting individual differences in ‘;brain reserve’. This review discusses the concept and possible determinants of brain reserve, and their implications for the diagnosis of Alzheimer's disease.