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Molecular Biology of Ageing: Age‐associated Attenuation in the Regulation of the Expression of Stress Response Genes
Author(s) -
Keidar Danit,
Efrati Edna,
Elaad Shlomit,
Shamovsky Ilya,
Weinreb Orly,
Lavie Lena,
Gershon David
Publication year - 1998
Publication title -
australasian journal on ageing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.63
H-Index - 34
eISSN - 1741-6612
pISSN - 1440-6381
DOI - 10.1111/j.1741-6612.1998.tb00861.x
Subject(s) - ageing , transcription factor , biology , gene , fight or flight response , microbiology and biotechnology , senescence , transcription (linguistics) , gene expression , hypoxia (environmental) , genetics , chemistry , linguistics , philosophy , organic chemistry , oxygen
. The attenuation in the capacity to respond to stress is one of the major characteristics of ageing organisms. There are several cellular pathways of response to various types of stress. We briefly discuss the NFkB pathway that is altered with age as was primarily shown by Papaconstantinou. We suggest that another important transcription factor system that should be investigated is that involved in the response to hypoxia. Our own work shows that the capacity to respond to elevated temperatures is considerably diminished in ageing organisms. Our studies demonstrate that this is due to faults in the control of the activation of the transcription factor, HSF, which is a major protein that activates many stress response genes. The nature of the alteration of the control of HSF with age is described and discussed.