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Stability of the reproductive variables and fetal malformations from control animals and animals treated with thalidomide in K bl: JW rabbits over two decades
Author(s) -
Kawamura Yoshinori,
Matsumoto Kiyoshi,
Sato Keiichiro
Publication year - 2012
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2012.00380.x
Subject(s) - thalidomide , fetus , embryo , congenital malformations , medicine , pregnancy , physiology , teratology , andrology , biology , genetics , multiple myeloma
We retrospectively analyzed the reproductive variables and the spontaneous malformations in the historical control data from the embryo‐fetal development studies conducted in our laboratories with K bl: JW rabbits over two decades (1990–2010) and fetal malformations induced by thalidomide in 1988, 1995 and 2007. These analyses in the control animals revealed that the reproductive variables in dams, total frequencies and profile of external, visceral and skeletal abnormalities and/or variations in the fetuses were stable over two decades. In addition, the characteristics of the malformations induced by thalidomide were reproducible at the three time points. Therefore, it is concluded that K bl: JW rabbit is one of the useful rabbit strains to evaluate the effects of test substances on embryo‐fetal development, especially in view of the chronological stability of spontaneous or drug‐induced malformations in the fetuses.