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Historical control data on prenatal developmental toxicity studies in rabbits
Author(s) -
Ema Makoto,
Aoyama Hiroaki,
Arima Akihiro,
Asano Yuzo,
Chihara Kazuhiro,
Endoh Katsumi,
Fujii Sakiko,
Hara Hiroaki,
Higuchi Hashihiro,
Hishikawa Atsuko,
Hojo Hitoshi,
Horimoto Masao,
Hoshino Nobuhito,
Hosokawa Yoshinori,
Inada Hiroshi,
Inoue Ayumi,
Itoh Keiichi,
Izumi Hiroyuki,
Maeda Maki,
Matsumoto Kiyoshi,
Matsuo Seiki,
Matsuura Ikuo,
Mineshima Hiroshi,
Miwa Yoji,
Miyata Hidenori,
Mizoguchi Yasumoto,
Nakano Nao,
Naya Masato,
Nishizawa Hanako,
Noritake Kenichi,
Noyori Hiroko,
Ohta Takafumi,
Oku Harutaka,
Shimizu Tatsuya,
Shimomura Kazuhiro,
Shiozawa Kei,
Takakura Ikuro,
Tanaka Ryota,
Uesugi Tohru,
Yabe Kaoru,
Yamauchi Toshiaki,
Yokoi Ryohei
Publication year - 2012
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2012.00365.x
Subject(s) - developmental toxicity , fetus , prenatal development , physiology , toxicity , pregnancy , medicine , teratology , reproductive toxicity , biology , obstetrics , genetics
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994–2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits were used for prenatal developmental toxicity studies. The data included maternal reproductive findings at terminal cesarean sections and fetal findings including spontaneous incidences of morphological alterations. No noticeable differences between strains or laboratories were observed in the maternal reproductive and fetal developmental data. The inter‐laboratory variations in the incidences of fetal external, visceral, and skeletal alterations seem to be due to differences in the selection of observation parameters, observation criteria, and classification of the findings, and terminology of fetal alterations.