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Gastric hairballs in rabbits: Significance in developmental toxicity study
Author(s) -
Fukumura Kanako,
Haneda Ryo,
Endoh Takako,
Takano Masao,
Mizoguchi Yasumoto,
Matsuoka Tetsuya,
Asano Yuzo
Publication year - 2012
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2012.00361.x
Subject(s) - toxicity , developmental toxicity , incidence (geometry) , physiology , statistical significance , medicine , abortion , body weight , food consumption , toxicology , biology , pregnancy , fetus , physics , agricultural economics , optics , economics , genetics
We surveyed 1053 pregnant rabbits of the Kbl:NZW strain collected from 27 developmental toxicity studies to reveal the prevalence and significance of gastric hairballs. The incidence of hairballs was 2/525 (0.4%) in the control group and 17/528 (3.2%) in the high dose group. In the high dose group, 16 dams resulted in abortion or death. In addition, decreases in body weight and food consumption were more severe in dams with hairballs than in their group‐mates without hairballs.