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Early embryonic losses in mice induced by diethylstilbestrol
Author(s) -
Nagao Tetsuji,
Yoshimura Shinsuke
Publication year - 2009
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2009.00247.x
Subject(s) - decidua , diethylstilbestrol , uterus , trophoblast , placenta , lumen (anatomy) , andrology , fetus , hypoplasia , medicine , biology , pregnancy , endocrinology , hormone , genetics
Estrogens cause embryonic lethality and the disturbance of early placental development in mice. Diethylstilbestrol (DES) at 1, 10, or 100 µg/kg was orally administered to Institute of Cancer Research mice on gestational days (GD) 4 through 8, and the uterus and placenta were examined histopathologically on GD 9. Decidua of DES‐treated mice showed insufficient development, and the uterine lumen at the implantation site did not effectively minimize. The trophoblast giant cell layer was not separated from the uterine lumen by the decidua capsularis, and hemorrhage from the denuded trophoblast giant cell layer into the uterine lumen was noted at the peripheral part of the decidua basalis. The results of the present study suggest that decidual hypoplasia and subsequent placental hemorrhage causes fetal death due to the administration of DES during the early stage of pregnancy.