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Metabolic fingerprinting of amniotic fluid from the streptozotocin‐induced diabetic pregnant rat using Fourier transform‐ion cyclotron resonance mass spectrometry
Author(s) -
Hasegawa Mina,
Tanaka Katsuhiro,
Takenaka Shigeo
Publication year - 2008
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2008.00193.x
Subject(s) - amniotic fluid , fourier transform ion cyclotron resonance , streptozotocin , diabetes mellitus , medicine , selected ion monitoring , mass spectrometry , endocrinology , fetus , pregnancy , ion cyclotron resonance , chemistry , ion , chromatography , biology , cyclotron , gas chromatography–mass spectrometry , genetics , organic chemistry
Metabolic fingerprinting of amniotic fluid from streptozotocin‐induced diabetic pregnant rats was performed using Fourier transform‐ion cyclotron resonance mass spectrometry. Some of the fetuses from the diabetic pregnant rats exhibited ventricular septal defect. The positive ion profiles of amniotic fluids from diabetes were different to those of the control rats. The alteration of biochemical composition in the diabetic amniotic fluid suggests the presence of potential biomarkers to indicate progression of malformation under the diabetic pregnancy.