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Clock mutant mice with Jcl/ICR background shows an impaired learning ability in water maze, but not in passive avoidance, at the beginning of dark phase
Author(s) -
Sei Hiroyoshi,
Oishi Katsutaka,
Sano Atsuko,
Seno Hiromasa,
Ohmori Tetsuro,
Morita Yusuke,
Ishida Norio
Publication year - 2006
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2006.00107.x
Subject(s) - microdialysis , morris water navigation task , hippocampal formation , hippocampus , circadian rhythm , acetylcholine , cholinergic , water maze , neuroscience , medicine , endocrinology , in vivo , chemistry , psychology , dopamine , biology , genetics
We observed the learning ability in Clock mutant mice with Jcl/ICR background (Clockj), a mice model of evening‐type individuals, in the early part of dark phase. In order to estimate the learning ability, Morris water maze (WM) and passive avoidance (PA) test were performed. Release of acetylcholine, 5 hydroxytryptophan (5‐HT) and dopamine (DA) in hippocampus was measured by in vivo microdialysis method. Clockj showed the impaired learning ability in the WM, but not in PA test. Hippocampal acetylcholine release was significantly attenuated in the Clockj in comparison to the wild‐type mice. Neither 5‐HT nor DA in the hippocampus was affected by the Clock mutation. Clock , an essential gene controlling circadian rhythm, may have an important role on the spatial learning and hippocampal cholinergic function, at least, at the beginning of the dark phase.