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Assisted reproductive technologies and birth defects
Author(s) -
Shiota Kohei,
Yamada Shigehito
Publication year - 2005
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.2005.00061.x
Subject(s) - intracytoplasmic sperm injection , assisted reproductive technology , in vitro fertilisation , angelman syndrome , infertility , reproductive technology , medicine , offspring , obstetrics , reproductive medicine , gynecology , pregnancy , biology , lactation , biochemistry , genetics , gene
  In vitro fertilization (IVF) and other assisted reproductive technologies (ART) are effective treatments for infertility and are widely provided at infertility clinics. Although IVF and related ART procedures are generally considered safe, some studies have suggested an excess occurrence of major malformations, low birth‐weight and other perinatal complications in babies conceived by ART. Further, it was recently reported that IVF and intracytoplasmic sperm injection (ICSI) are associated with imprinting disorders in the offspring such as Beckwith‐Wiedemann syndrome and Angelman syndrome. Here we review the human and animal studies investigating the potential risks of ART, and discuss the need for further investigation.

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