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Species Difference in Developmental Toxicity of an N‐Phenylimide Herbicide between Rats and Rabbits and Sensitive Period of the Toxicity to Rat Embryos
Author(s) -
KAWAMURA Satoshi,
KATO Terushige,
MATSUO Masatoshi,
SASAKI Madoka,
KATSUDA Yoko,
HOBERMAN Alan M.,
YASUDA Mineo
Publication year - 1995
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1995.tb00306.x
Subject(s) - toxicity , developmental toxicity , gestation , teratology , embryo , fetus , biology , andrology , physiology , toxicology , medicine , endocrinology , pregnancy , microbiology and biotechnology , genetics
An N‐phenylimide herbicide, S‐53482, exhibited developmental toxicity in rats in the absence of maternal toxicity at a dose of 30 mg/kg. The developmental toxicities noted were embryolethality, teratogenicity (mainly ventricular septal defect [VSD] and wavy ribs) and growth retardation. In contrast to rats, the herbicide showed no developmental toxicity in rabbits even at a maternal toxic dose of 3,000 mg/kg. There was a remarkable species difference between rats and rabbits. A single dose of S‐53482 was administered to pregnant rats on one of gestation days 11 through 15 (detection of plug = day 0). Day 12 of gestation was the most sensitive day for embryonic death, VSD, and decreased fetal body weight. It is likely that there is a common mechanism for the three types of developmental toxicity and that S‐53482 does not produce VSD by its direct damage to embryonic heart tissue.