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Micrencephaly in Rats Caused by Maternal Hyperthermia on Days 13 and 14 of Pregnancy 1
Author(s) -
HARDING Antony J.,
EDWARDS Marshall J.
Publication year - 1993
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1993.tb00527.x
Subject(s) - hyperthermia , rectal temperature , gestation , pregnancy , medicine , body weight , fetus , anesthesia , physiology , biology , genetics
Hyperthermia was induced in rats twice at an interval of eight hours on both days 13 and 14 of gestation by partial immersion in a water‐bath. Deep rectal temperature was raised to 42.5°C for five minutes. Body weights of newborn rats were reduced, but by three weeks of age compensatory post‐natal growth had eliminated the defect. In both newborn and 21‐day‐old rats, brain weight was significantly reduced compared with controls of similar body weight. No other anomalies were found.