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Rib Defects and Pattern Formation of the Thoracic Wall Muscles
Author(s) -
KINOSHITA Yuko,
MURAKAMI Gen,
KATAMACHI Ikuo,
HOSHI Hajime
Publication year - 1993
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1993.tb00516.x
Subject(s) - somite , quail , notochord , anatomy , rib cage , cartilage , embryo , biology , microbiology and biotechnology , embryogenesis , endocrinology
A fragment of quail notochord (20 somite stage) was implanted into a host chick embryo (25–30 somite stage) just lateral to the thoracic somites or into the intersomitic space. Around the implanted notochord, aggregates of rib‐forming sclerotomal cells formed a large irregular mass of cartilage, resulting in segmental rib defects without any adverse effect on body wall muscle formation. This contrasted sharply with previous experimental studies in which abnormalities of other somite derivatives, in particular body wall muscles, were always associated with rib defects created by teratogenic agents, surgidal treatment or by genetic means. These results suggest that migration of myogenic cells into the thoracic wall does not require the guidance of rib‐forming sclerotomal cells or their products. Moreover, those myogenic cells can develop into three layers of thoracic wall muscles, independent of skeletal pattern formation.