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Diaphragmatic Hernia Induced in Rat Fetuses by Administration of Bisdiamine
Author(s) -
TASAKA Hiroyasu,
TAKENAKA Hitoshi,
OKAMOTO Naomasa,
KOGA Yasunori,
A Minora HAMAD
Publication year - 1992
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1992.tb00259.x
Subject(s) - congenital diaphragmatic hernia , medicine , gestation , diaphragmatic hernia , hernia , diaphragmatic breathing , fetus , incidence (geometry) , serous fluid , surgery , pregnancy , pathology , biology , genetics , alternative medicine , physics , optics
Administration of N, N'‐bis (dichloroacetyl)‐l,8‐octamethylenediamine, bisdiamine, to pregnant Donryu rats on a single day of gestation induced unilateral and bilateral diaphragmatic hernias in fetuses with high incidence. The protruded liver was not covered with a serous membrane or a muscular layer. Incidence of unilateral diaphragmatic hernia on the left side was high when bisdiamine was administered on day 9 or 13 of gestation, and that on the right side was high when administered on day 12 of gestation. Incidence of bilateral diaphragmatic hernia was high when bisdiamine was administered on day 12 of gestation. Differences in sensitivity to hernia formation according to day of bisdiamine administration between right and left sides may reflect differences in developmental chronology between the two sides. Two distinct times for induction of left diaphragmatic hernia might be attributed to at least two different mechanisms. The present model is expected to help analyzing not only anatomical characteristics of congenital diaphragmatic hernia but also possible mechanisms responsible for their development.

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