Premium
Teratogenicity of Anti‐testis Antiserum in Mice
Author(s) -
TAKAYAMA Yohichi,
WATANABE Masatomo,
YAMAMOTO Masaharu
Publication year - 1986
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1986.tb00666.x
Subject(s) - antiserum , fetus , andrology , basement membrane , antigen , medicine , deformity , biology , pregnancy , anatomy , immunology , surgery , genetics
The teratogenicity of anti‐testis antiserum was confirmed by an experiment using C57BL/6J mice. When the antiserum was administered intraperitoneally to females on day 12.5 of pregnancy, reduction deformity of limbs and cleft palates were produced in the fetuses. Examinations of the internal organs and skeletons revealed no abnormality in the antiserum‐treated mice. Immuno‐histological analysis suggests the possibility that some antigen in the testis basement membrane may be involved.