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On the Fine Structure of Ito's Fat‐Storing Cells in the Liver of the Mouse Fetus after Maternal Treatment with Vitamin A
Author(s) -
KOBAYASHI Kan,
IWASAKI Shinichi,
TAKAHASHI Keiichi,
UENO Minako,
IGARASHI Azuma,
NAGAI Hiroshi,
SUZUKI Kazunori,
KATSUYA Tamio
Publication year - 1985
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1985.tb01008.x
Subject(s) - fetus , gestation , vitamin , placenta , pregnancy , lipid droplet , medicine , endocrinology , hepatic stellate cell , liver cell , cell , physiology , andrology , biology , biochemistry , genetics
The purpose of this study is to ascertain possible cytological effects of vitamin A administration to pregnant mice on the fat‐storing cells (Ito cell) in the fetus liver. Though many external anomalies were occurred in the fetus when vitamin A was given once on day 8 of gestation, it is conceivable that the appearance of these teratogenicity may not be concerned in Ito cell because liver had not yet developed at this stage. When vitamin A was given once a day for four days consecutively from day 14 to day 17 of gestation little external anomalies were appeared. By electron microscopy, cytological changes were found in Ito cell, especially the number of lipid droplets in the cytoplasm conspicuously increased. This proved that vitamin A administered to the mothers was carried into the fetuses through the placenta and Ito cells of the fetus liver had an ability to absorb vitamin A at the late stage of pregnancy.