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Developmental Change of Hematological Features of the Anemic CFO Mouse ( heal hea) with Hereditary Congenital Erythroblastic Anemia
Author(s) -
SHIMIZU Koji,
KEINO Hiromi,
MIZUTANI Akira
Publication year - 1985
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1985.tb01001.x
Subject(s) - anemia , hematocrit , hemoglobin , bone marrow , medicine , andrology
Developmental changes of hematological features of anemic CFO mice ( hea/hea ) were studied in comparison with those of normal mice (+/+ or hea /+). Anemia of newborn hea/hea mice was not severe, but was easily distinguishable from normal littermates by their yellow body color and also by their blood smear pictures which showed abundant erythroblasts. This disease proceeded rather progressively though many died around 10 days after birth and none survived after aged 25 days. Erythrocyte count, hematocrit percentage and hemoglobin content of hea/hea mice became to be nearly 50% of those of normals during development. On the other hand, leukocyte number of hea/hea mice was 3 to 8 times as many as that of normals. Although hepatomegaly was not evident, splenomegaly was remarkable in hea/hea mice after aged 15 days: Platelet number of hea/hea was about 3 times as many as that of normals. On the contrary, megakaryocytes in the bone marrow of hea/hea mice were much fewer than those of normals. Nucleated cells, mainly orthochromatophilic erythroblasts, in the circulation of hea/hea mice were strikingly 80 to 100 times as many as those of normals. This progressively developed anemia caused by hea seemingly affected the differentiation of erythroid cells, but also that of myeloid cells and that of megakaryocytes.