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Birth Defects Monitoring in the Tokyo Metropolitan Hospitals: Methods and Some Preliminary Results *
Author(s) -
KONDO Kiyotaro
Publication year - 1984
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1984.tb00939.x
Subject(s) - syndactyly , polydactyly , medicine , gestational age , metropolitan area , pediatrics , downtown , pregnancy , genetics , biology , anatomy , pathology
All 55,103 neonates, including 808 stillbirths after the 16th gestational week, born in 11 Tokyo Metropolitan hospitals during April 1978 December 1982, were monitored. Neonates with recognizable birth defects within 1 postnatal week were exhaustively collected. 4,006 neonates showed one or more of the defects, but major defects with functional impairments were observed in 698, or 1.3% of the neonates, being identical to the figures in other reports. Mutliple defects totaled 464, including 54 chromosome anomalies and 30 genetic syndromes. Of 3,541 single defects, 3,126 were classifiable by the codes for the birth defects in the International Classification of Diseases. Temporal trends were evaluated with three methods in 17 selected defects including 11 designated by the Clearinghouse. The results were 1) a rise was alway transient and random being followed by a period with the base‐line frequency, the overall trends being stationary, 2) a sharp rise of anencephalus in July, 1982 was due to four cases happened within several kilometers in downtown Tokyo around Koto‐ku area, 3) Polydactyly and syndactyly showed identical results, 4) suitableness of three methods were compared with basically identical results.