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The Effects of M‐protein Fraction of Hemolytic Streptococci on Embryonic Development in the Rat
Author(s) -
MIYATA Koichiro,
ONO Seigo,
NINOMIYA Makoto,
JITOSHO Tamotsu,
TACHIKURA Junko,
TERAWAKI Tamotsu
Publication year - 1984
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1984.tb00933.x
Subject(s) - microphthalmia , anophthalmia , antibody , gestation , fetus , myocarditis , teratology , endocarditis , andrology , embryonic heart , embryo , pregnancy , biology , chemistry , endocrinology , medicine , immunology , pathology , embryonic stem cell , biochemistry , microbiology and biotechnology , genetics , gene
Wistar rats were administered M‐protein fraction (MP) of group A type 12 hemolytic streptococci or rabbit anti‐MP serum (AMPS) on day 9 of gestation. The incidence of malformations was 11.8% when 9 mg/kg of MP was administered and 12.0% when 9 ml/kg of AMPS was injected. The main malformations observed in both groups were ventricular septal defect, microphthalmia, anophthalmia, and hydrocephaly. Light and electron microscopic studies revealed no myocarditis nor endocarditis in either the maternal or fetal heart. Fluorescent antibody technique demonstrated no localization of anti‐MP antibodies on the maternal heart. The results suggest that MP and AMPS are slightly teratogenic in the rat, and that the teratogenesis is not caused by an autoimmune mechanism.