Premium
Immunological Defects in a Bis(dichloroacetyl) diamine Induced Malformation Complex in Rats Closely Resembling the DiGeorge Syndrome
Author(s) -
OKISHIMA Takahiro,
EIZURU Yoshito,
MINAMISHIMA Yoichi,
OHDO Shozo,
HAYAKAWA Kunio
Publication year - 1984
Publication title -
congenital anomalies
Language(s) - English
Resource type - Journals
eISSN - 1741-4520
pISSN - 0914-3505
DOI - 10.1111/j.1741-4520.1984.tb00365.x
Subject(s) - concanavalin a , digeorge syndrome , lipopolysaccharide , spleen , immunology , biology , endocrinology , medicine , genetics , in vitro
ABSTRACT: Spleen cells from newborn rats with bisdiamine‐induced congenital malformation were examined for subpopulation of lymphocytes and responsiveness of the lymphocytes to phytohemagglutinin (PHA), concanavalin A (ConA) and lipopolysaccharide (LPS). T cells, but not B cells, were significantly diminished in the drug‐treated newborn rats. Proliferative response of the lymphocytes to PHA and ConA, but not to LPS, was significantly depressed in the drug‐treated newborns. Thus a defect in cell‐mediated immunity was suggested to be associated with the congenital anomaly. It is tempting to consider that this bisdiamine‐induced malformation can be another animal model for the DiGeorge syndrome.