Antifungal and physical characteristics of modified denture base acrylic incorporated with silver nanoparticles

doi: 10.1111/j.1741‐2358.2011.00489.x Antifungal and physical characteristics of modified denture base acrylic incorporated with silver nanoparticles Objective:  This study evaluated the antifungal and physical characteristics of denture base acrylic combined with silver nanoparticles. Materials and methods:  Polymerized denture acrylic disc specimens containing 0 (control), 1.0, 5.0, 10.0, 20.0 and 30.0 wt% of silver nanoparticles were placed on separate culture plate dish and 100 ìL samples of yeast suspension of Candida albicans strain were inoculated on each specimens and incubated at 37°C, for 24 h. The antifungal effects were evaluated as a number of viable cells in retrieved fungal suspension. To characterize physical aspects, specimens were tested for elution of silver cation (Ag + ) at 24 h and 30th day, thermal analysis (TG/DTA), scanning electron microscope and energy dispersed X‐ray analysis (SEM/EDX) and color stability. Results:  Significant reduced CFU was exhibited at 20.0 and 30.0 wt% of silver nanoparticles incorporated (p < 0.01) and Ag + elution from specimens (maximum 0.356 ± 0.11 mg/L) contributed little to the antifungal activity considering MIC of Ag + in this study (3.0 mg/L). The successful synthesis of modified denture acrylic containing silver nanoparticles was accessed by TG/DTA and EDX analysis. Conclusion:  The modified denture base acrylic combined with silver nanoparticles displayed antifungal properties and acted like latent antifungal material itself with low‐releasing Ag + , however, the improvement of poor color stability was still required.