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Effects of Furosemide on the Oral Cavity
Author(s) -
Atkinson Jane C.,
Shiroky Jeffrey B.,
Macynski Alice,
Fox Philip C.
Publication year - 1989
Publication title -
gerodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 54
eISSN - 1741-2358
pISSN - 0734-0664
DOI - 10.1111/j.1741-2358.1989.tb00398.x
Subject(s) - furosemide , medicine , diuretic , placebo , ingestion , oral cavity , salivary gland , oral administration , loop diuretic , endocrinology , renal function , dentistry , pathology , alternative medicine
Furosemide, a potent loop diuretic, has been reported to cause xerostomia, a sensation of oral dryness. We obtained urine and salivary secretions from five normal males after oral intake of either 0.5 mg/kg body weight of furosemide or placebo. The experimental treatment resulted in a five‐fold increase in urinary output. In contrast, analysis of salivary secretions indicated there were no significant differences in flow rates, total output, total protein, or Na*, K + , or Cl − concentrations following drug or placebo. Subjectively, xerostomia was experienced 10 times more frequently after ingestion of furosemide. These data suggest that, in vivo , furosemide had a greater effect on the kidney than on the salivary gland and that the sensation of oral dryness is not solely a function of the quantitative salivary output.