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USE OF FORCE PLATE ANALYSIS TO EVALUATE THE EFFICACY OF EXTERNAL BEAM RADIATION TO ALLEVIATE OSTEOSARCOMA PAIN
Author(s) -
WEINSTEIN JEFF I.,
PAYNE SARAH,
POULSON JEAN M.,
AZUMA CHIEKO
Publication year - 2009
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2009.01602.x
Subject(s) - osteosarcoma , medicine , amputation , radiation therapy , nuclear medicine , external beam radiation , lameness , external beam radiotherapy , chemotherapy , population , surgery , brachytherapy , pathology , environmental health
A standard of therapy for osteosarcoma includes amputation with or without adjuvant chemotherapy. There is a subset of dogs with osteosarcoma that are unsuitable for amputation. We evaluated kinetic variables in dogs with appendicular osteosarcoma treated with a single 8 Gy dose of radiation. Eighteen pet dogs with appendicular osteosarcoma received one 8 Gy fraction of palliative radiation on day 0. Force plate measurements and clinical assessments were made on days 0, 7, 14, and 21. Peak vertical forces ( F z ) were recorded for each limb and a symmetric index (SI) was calculated. There were no significant changes in kinetic parameters after one 8 Gy dose of radiation therapy. Nine of these 18 dogs exhibited increased limb function at day 21 based on force plate analysis. Significant factors affecting F z included gender and tumor location. There was a significant correlation between F z and response to therapy based on SI at day 21. SI seems to be useful to objectively assess response in this mixed population of dogs. One 8 Gy fraction of radiation therapy alone did not reduce lameness associated with appendicular osteosarcoma, but a subset of dogs did have improved limb function after a single dose.