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REGIONAL BRAIN PERFUSION IN EPILEPTIC DOGS EVALUATED BY TECHNETIUM‐99m‐ETHYL CYSTEINATE DIMER SPECT
Author(s) -
MARTLÉ VALENTINE,
PEREMANS KATHELIJNE,
AUDENAERT KURT,
VERMEIRE SIMON,
BHATTI SOFIE,
GIELEN INGRID,
POLIS INGEBORGH,
VAN HAM LUC
Publication year - 2009
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2009.01600.x
Subject(s) - ictal , medicine , epilepsy , cerebral blood flow , technetium 99m , perfusion , nuclear medicine , single photon emission computed tomography , perfusion scanning , cerebellum , radiology , scintigraphy , psychiatry
We evaluated the feasibility of interictal single photon emission computed tomography (SPECT) to detect alterations in regional cerebral blood flow and neuronal activity in dogs with idiopathic epilepsy. Twelve dogs with idiopathic epilepsy underwent interictal technetium‐99m‐ethyl cysteinate dimer SPECT of the brain. Different cortical regions of interest (ROIs), 1 ROI at the cerebellum and 1 ROI at the subcortical area were evaluated by semiquantitative analysis and compared with a control group (18 dogs). Significant hypoperfusion ( P =0.02) was present in the subcortical area of epileptic dogs. This hypoperfusion was not associated with seizure frequency, age at onset of seizures, duration of epilepsy, or time since the last seizure. Interictal SPECT did not reveal cortical or cerebellar perfusion alterations. The subcortical area may play an important role in the pathophysiology of canine idiopathic epilepsy.