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A NINE‐DAY ACCELERATED RADIATION PROTOCOL FOR FELINE SQUAMOUS CELL CARCINOMA
Author(s) -
FIDEL JANEAN L.,
SELLON RANCE K.,
HOUSTON ROBERT K.,
WHEELER BETSY A.
Publication year - 2007
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2007.00283.x
Subject(s) - medicine , cats , basal cell , radiation therapy , overall survival , toxicity , complete response , surgery , chemotherapy
Nine cats with oral squamous cell carcinoma were treated with an accelerated radiation protocol (14 fractions of 3.5 Gy in 9 days). Radiation was administered twice daily with a 6 hour break between treatments. Median overall survival was 86±110 days. Median survival for cats with a partial response ( n =6) was 60±7 days, while median survival for cats with a complete response ( n =3) was 298±187 days ( P =0.0639). The accelerated protocol was well tolerated and toxicity in the early and late period was manageable in all cats. Further modification of the protocol is warranted to extend survival.