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PRELIMINARY EVALUATION OF 99m TECHNETIUM DIETHYLENETRIAMINE PENTAACETIC ACID, 99m TECHNETIUM DIMERCAPTOSUCCINIC ACID, AND 99m TECHNETIUM MERCAPTOACETYLTRIGLYCINE FOR RENAL SCINTIGRAPHY IN CORN SNAKES ( ELAPHE GUTTATA GUTTATA )
Author(s) -
SYKES JOHN M.,
SCHUMACHER JUERGEN,
AVENELL JAMES,
RAMSAY EDWARD,
DANIEL GREGORY B.
Publication year - 2006
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2006.00131.x
Subject(s) - dimercaptosuccinic acid , technetium 99m , nuclear medicine , medicine , scintigraphy , technetium , isotopes of technetium , technetium 99 , kidney
The efficacy of three radiopharmaceuticals, 99m Tc‐diethylenetriaminepentaacetic acid ( 99m Tc‐DTPA), 99m Tc‐dimercaptosuccinic acid ( 99m Tc‐DMSA), and 99m Tc‐mercaptoacetyltriglycine ( 99m Tc‐MAG 3 ), for renal imaging was examined in 16 corn snakes ( Elaphe guttata guttata ). All snakes received the radiopharmaceutical via an intracardiac injection. The kidneys could not be visualized in the three snakes that received 99m Tc‐DTPA or in the three snakes that received 99m Tc‐DMSA, but were well delineated in all 10 snakes receiving 99m Tc‐MAG 3 . These snakes were anesthetized and a dynamic frame mode acquisition was obtained for 30 min immediately following injection. A 60 s single static frame mode image was then obtained with the snake in a curled position. Two of the 10 snakes that received 99m Tc‐MAG 3 were removed from further analysis because of suspected pericardial injections. Of the remaining eight snakes, the mean (±SD) renal uptake was 25±9.8% or 24±9.7%, with or without correction for residual injection site activity, respectively. Correction for remaining radioactivity in the heart does not appear to be necessary if it is less than 10% of the total dose. 99m Tc‐MAG 3 provided consistently high quality images of the kidneys and further studies are warranted to evaluate its sensitivity for detecting decreased function in snakes with renal disease.