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99M TC‐CIPROFLOXACIN IN IMAGING OF CLINICAL INFECTIONS IN CAMELIDS AND A GOAT
Author(s) -
Alexander Kate,
Drost Wm Tod,
Mattoon John S.,
Anderson David E.
Publication year - 2005
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2005.00064.x
Subject(s) - ciprofloxacin , medicine , urinary system , nuclear medicine , abdomen , radiology , antibiotics , biology , microbiology and biotechnology
99m Tc‐ciprofloxacin was used to image five adult camelids and a juvenile goat with clinical and/or radiographic signs of infection. 99m Tc‐ciprofloxacin (range 10–33 MBq/kg) was injected intravenously and a series of 2‐min static images were acquired at 1‐ and 4‐h postinjection. At 24‐h postinjection, 5‐min static images were acquired. Only the skull or abdomen was imaged in the adults; the whole body was imaged in the goat. The quality of the 1‐, 4‐, and 24‐h studies was evaluated subjectively. Normal and abnormal areas of 99m Tc‐ciprofloxacin uptake were recorded and subjectively graded as mild, moderate or intense. Image quality was best 4‐h postinjection. Twenty‐four‐hour images were poor because of insufficient radioactivity. 99m Tc‐ciprofloxacin imaging resulted in true positive or true negative scans in four of six animals. Two false‐negative studies occurred. Intense 99m Tc‐ciprofloxacin activity was seen in the lungs and urinary bladder, moderate/intense activity in the kidneys, and mild activity in the physes/epiphyses, liver and intermittently in the gastrointestinal tract. The normal distribution of 99m Tc‐ciprofloxacin in camelids/small ruminants differed from people. Further studies to determine the sensitivity and specificity of infection detection using 99m Tc‐ciprofloxacin in animals are warranted.