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Cobalt Radiation with or without Low‐Dose Cisplatin for Treatment of Canine Naso‐Sinus Carcinomas
Author(s) -
Nadeau MarieEve,
Kitchell Barbara E.,
Rooks Robert L.,
LaRue Susan M.
Publication year - 2004
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2004.04068.x
Subject(s) - medicine , azotemia , cisplatin , radiation therapy , sinus (botany) , toxicity , urology , surgery , chemotherapy , renal function , botany , biology , genus
The objective of this study was to determine if low‐dose cisplatin could be added safely to radiation therapy for the treatment of naso‐sinus carcinomas in dogs. Thirty‐one dogs were evaluated; 18 of these dogs received cobalt radiation in combination with low‐dose cisplatin while 13 dogs received radiation alone. No difference was observed for acute or late radiation effects. Cisplatin was administered at a dosage of 7.5 mg/m 2 20 min prior to every other radiation treatment. An initial dose of 10 mg/m 2 was intended but toxicity (primarily azotemia) was unacceptable. Cisplatin was administered as prescribed in 12 of 18 dogs. Cisplatin was discontinued in 2 dogs because of azotemia. In the other 4 dogs cisplatin was not administered as prescribed because the dogs were withdrawn from treatment due to disease progression or radiation effects. There was no long‐term renal disease in patients who developed azotemia. The overall median survival was 433 days with 4 (12.9%) dogs still alive at the completion of the study.