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QUANTITATIVE AND QUALITATIVE SCINTIGRAPHIC MEASUREMENT OF RENAL FUNCTION IN DOGS EXPOSED TO TOXIC DOSES OF GENTAMICIN
Author(s) -
LoraMichiels Michaël,
Anzola Kelly,
Amaya Germän,
Solano Mauricio
Publication year - 2001
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2001.tb00986.x
Subject(s) - gentamicin , medicine , renal function , creatinine , effective renal plasma flow , urology , blood urea nitrogen , renal blood flow , kidney , antibiotics , chemistry , biochemistry
Five, 3‐month‐old mongrel dogs weighing between 4.5 to 5.5 kg were studied to evaluate and compare the efficiency of 99m Tc‐DTPA, 99m Tc‐MAG, and 99m Tc‐DMSA in detecting gentamicin‐induced renal tubular injury. After baseline renograms using all three methods, all dogs received daily intramuscular injections of gentamicin at a dose of 30–45 mg/kg. Additional studies were obtained after a cumulative dose of 450, 1,575, and 2,250 mg of gentamicin was reached. Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and percentage of total renal uptake measurements were calculated. Baseline and post‐gentamicin injection blood urea nitrogen (BUN) and serum creatinine values were determined. A Duncan test revealed significant renal function impairment at 450 mgs of cumulated gentamicin with 99m Tc‐DMSA and at 1,575 mgs of cumulated gentamicin for 99m Tc‐DTPA and 99m Tc‐MAG., There was no correlation between BUN and serum creatinine values when compared to gentamicin (p > 0.05). The images obtained with 99m Tc‐MAG, were of better quality than those obtained with 99m Tc‐DTPA even under severe renal dysfunction. Percentage of 99m Tc‐DMSA uptake indicated renal damage, before than GFR and ERPF. BUN and serum creatinine measurements were poor indicators of gentamicin‐induced renal failure.