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EVALUATION OF HEART TIME‐ACTIVITY CURVES AS A PREDICTOR OF HEPATIC EXTRACTION OF 99m Tc‐MEBROFENIN IN DOGS
Author(s) -
Daniel Gregory B.,
DeNovo Robert,
Bahr Anne,
Smith Gary T.
Publication year - 2001
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.2001.tb00920.x
Subject(s) - medicine , hepatic function , extraction (chemistry) , area under the curve , chromatography , chemistry
In this study, heart time‐activity curve, created following intravenous injection of 99m Tc‐mebrofenin were used to quantify hepatic function in normal dogs and dogs with induced hepatic parenchymal cell damage. The results were compared to a direct measurement of hepatic extraction following mesenteric venous injection of 99m Tc‐mebrofenin. The heart time‐activity curves were normalized and the area under the curve from 0–30 minutes and 0–60 minutes were determined. In addition, the half‐time clearance rate of the heart time‐activity curve was analyzed using a two‐compartment model. Linear regression analysis was used to describe the relationship between the area under the normalized heart time‐activity curve and hepatic extraction. There was good correlation between the area under the normalized heart time‐activity curve and hepatic extraction. The best correlation was obtained from the 0–30 minute data (r 2 = 0.92). A formula for calculating hepatic extraction was derived using linear regression analysis: Hepatic extraction = 1.092 ‐ (0.0000308 × AUC 0–30 minutes). There was good correlation between the half‐time clearance rates from the heart time‐activity curve and hepatic extraction. The best correlation was between the fast phase half‐time clearance and hepatic extraction (r 2 = 0.88). The area under a normalized heart time‐activity curve can be used as a simple alternative to decon‐volutional analysis for the determination of hepatic extraction as a measure of hepatic parenchymal cell function in the dog.