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RENAL TRANSIT TIME OF 99m Tc‐DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) IN NORMAL DOGS
Author(s) -
Barthez Paul Y.,
Wisner Erik R.,
DiBartola Stephen P.,
Chew Dennis J.
Publication year - 1999
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.1999.tb00894.x
Subject(s) - medicine , mean transit time , transit time , kidney , renal function , nuclear medicine , renal artery , scintigraphy , aorta , cardiology , perfusion , perfusion scanning , transport engineering , engineering
The transit time of 99m Tc‐DTPA in the kidneys is an indicator of renal function that has been used in humans for the diagnosis of renal obstruction, renal artery stenosis, and rejection of renal transplants. Its use, however, has not been reported in the dog. 99m Tc‐DTPA scintigraphy was performed in 8 normal dogs and the time of peak was calculated as the time between the injection and the maximum renal uptake. Deconvolution analysis was performed to estimate the renal retention function using 3 different techniques, i.e. the matrix method, the fast Fourier transform (FFT) method, and the constrained least square method. The parenchymal and whole kidney mean transit times were calculated from the deconvolved renogram using alternatively the thorax and the aorta as the input function. Average mean transit times ranged from 137 to 184 seconds. Parenchymal mean transit time was significantly shorter than whole kidney mean transit time ( P < 0.03). Mean transit time calculated with the thorax as the input function was significantly longer than mean transit time calculated with the aorta ( P < 0.001). No differences were observed between mean transit time calculated with the matrix, FFT and constrained least square methods.