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COMPARISON BETWEEN THE SCINTIGRAPHIC UPTAKE AND PLASMA CLEARANCE OF 99 m Tc‐DIETHYLENETRIAMINEPENTACETIC ACID (DTPA) FOR THE EVALUATION OF THE GLOMERULAR FILTRATION RATE IN DOGS
Author(s) -
Barthez Paul Y.,
Hornof William J.,
Cowgill Larry D.,
Neal Larry A.,
Mickel Paul
Publication year - 1998
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.1998.tb01636.x
Subject(s) - renal function , inulin , plasma clearance , clearance rate , medicine , clearance , kidney , pah clearance , filtration fraction , technetium , effective renal plasma flow , urology , endocrinology , nuclear medicine , renal blood flow , chemistry , pharmacokinetics , biochemistry
The scintigraphically measured percentage dose uptake of 99m Tc‐DTPA by the kidneys and the plasma clearance of 99m Tc‐DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99m Tc‐DTPA plasma clearance was better ( p =.0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99m Tc‐DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.