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RADIOTHERAPY OF CANINE NON‐TONSILLAR SQUAMOUS CELL CARCINOMA
Author(s) -
LaDueMiller Tracy,
Price G. Sylvester,
Page Rodney L.,
Thrall Donald E.
Publication year - 1996
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.1996.tb00817.x
Subject(s) - medicine , radiation therapy , basal cell , stage (stratigraphy) , surgery , carcinoma , nuclear medicine , paleontology , biology
The records of 14 dogs treated with megavoltage radiation for non‐tonsillar oral squamous cell carcinoma were reviewed to determine the efficacy of this treatment modality. Total radiation dose was either 48 or 57 Gray (Gy), while dose per fraction was either 3.0 or 4.0 Gy. Median disease free interval and survival were 365 and 450 days, respectively. Median disease free interval was shorter in dogs older than nine years (210 days) as compared with dogs less than or equal to nine years old (470 days), (p < .005). Median survival was shorter in dogs older than nine years (315 days) as compared with dogs less than or equal to nine years old (1080 days), (p < 0.02). Weight, stage, anatomic subsite, intraoral location, duration of disease, prior surgery, and number of radiation fractions did not appear to influence disease free interval or survival. Data presented herein suggest that survival in dogs with non‐tonsillar squamous cell carcinoma receiving megavoltage radiation may be longer than that achieved with orthovoltage radiation or surgery. Megavoltage radiation appears to be an effective treatment for non‐tonsillar oral squamous cell carcinoma in dogs. Further study is needed to determine the optimal time‐dose sched‐ule.