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THE NON‐CARDIAC DISTRIBUTION OF 99m TC‐METHOXY‐ISOBUTYL‐ISONITRILE (SESTAMIBI) IN NORMAL BEAGLES
Author(s) -
Steyn Phillip F.,
Ogilvie Gregory
Publication year - 1995
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.1995.tb00239.x
Subject(s) - medicine , distribution (mathematics) , cardiology , nuclear medicine , mathematical analysis , mathematics
Technetium‐99m methoxy‐isobutyl‐isonitrile (sestamibi) is a radiophartnaceutical used for the evaluation of myocardial perfusion. Increased uptake of sestamibi has also been documented in tumors. The objective of this study was to document the extracardiac biodistribution of 99m Tc sestamibi in the normal dog. Nine normal beagles were given 0.35 mCi/kg 99m Tc sestamibi intravenously, and 60 second images were made of the entire body at 1 hour post injection. A defined distribution pattern was recognized, with good visualization of the heart, liver, gallbladder, small intestine, kidneys, urinary bladder, popliteal lymph nodes, parotid salivary glands and zygomatic salivary glands. Splenic uptake was not seen. Target to background ratios were calculated for all the regions listed, using background regions‐of‐interest with the smallest coefficient of variance for the denominator. The mean, range and standard deviation of these ratios are given.