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NONSPECIFIC ACCUMULATION OF TC‐99M‐IMMUNOGLOBULINS IN CHRONIC AND ACUTE ARTHRITIS
Author(s) -
Papageorges Marc,
Gavin Patrick R.,
Barbee David D.,
Knowles Donald P.,
Cheevers William P.,
Sande Ronald D.
Publication year - 1992
Publication title -
veterinary radiology and ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 1058-8183
DOI - 10.1111/j.1740-8261.1992.tb01958.x
Subject(s) - medicine , synovitis , antibody , arthritis , in vivo , antigen , technetium , immunology , virology , nuclear medicine , biology , microbiology and biotechnology
During a study designed to investigate the potential of radioimmunodetection to detect lentiviral antigens in vivo , it was found that technetium‐99m‐labeled antibodies (Tc‐99m‐Abs) accumulated nonspecifically in arthritic joints of goats infected with the caprine arthritis‐encephalitis virus. The uptake of Tc‐99m‐Abs was significantly higher in both chronic and acute arthritis compared to normal joints, but similar to the uptake of Tc‐99m‐labeled human serum albumin (Tc‐99m‐HSA). Tc‐99m‐Abs could be used to detect synovitis but did not show any advantage over Tc‐99m‐HSA.