Premium
THE RHESUS MONKEY
Author(s) -
Silverman Sam,
Jagdis Frank,
Hoeprich Paul D.,
Merten Dave,
Morgan Joe P.
Publication year - 1982
Publication title -
veterinary radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.541
H-Index - 60
eISSN - 1740-8261
pISSN - 0196-3627
DOI - 10.1111/j.1740-8261.1982.tb01295.x
Subject(s) - pneumonia , leukocytosis , medicine , streptococcus pneumoniae , pleural effusion , pneumococcal pneumonia , bacteremia , lung , serotype , pathology , effusion , streptococcus , animal model , immunology , antibiotics , surgery , biology , microbiology and biotechnology , bacteria , genetics
Transbronchoscopic inoculation of five serotypes of Streptococcus pneumoniae was used to produce pneumonia in five rhesus monkeys. The development and resolution of the pneumonia were followed radiographically and clinically. The initial inoculation determined the lung lobes that would become involved. The acute state was accompanied by a febrile response, leukocytosis, and bacteremia. Resolution of the pneumonia occurred in six weeks. The radiographic features of spontaneous streptococcal pneumonia in rhesus monkeys were similar but not identical to those found in man. However, extension to other lobes, mediastinal lymphadenopathy, and extensive pleural effusion, as often noted in the human, were not identified. The rhesus monkey is thought to be a good animal model for the radiographic evaluation of streptococcal pneumonia.