Premium
Effect of calcitonin on adrenocorticotropic hormone secretion stimulated by corticotropin‐releasing hormone in the hen anterior pituitary
Author(s) -
NAKAYAMA Hiroyuki,
TAKAHASHI Tetsuya,
NAKAGAWAMIZUYACHI Kaori,
KAWASHIMA Mitsuo
Publication year - 2011
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/j.1740-0929.2010.00850.x
Subject(s) - anterior pituitary , adrenocorticotropic hormone , medicine , calcitonin , endocrinology , corticotropic cell , receptor , secretion , acth receptor , hormone , corticotropin releasing hormone , pituitary gland , chemistry , hormone receptor , peptide hormone , biology , cancer , breast cancer
The presence of a receptor for calcitonin (CT) and the effect of chicken CT (cCT) on adrenocorticotropic hormone (ACTH) secretion stimulated by rat/human corticotropin‐releasing hormone (rhCRH) in the hen anterior pituitary were studied. The specific [ 125 I]cCT binding component was present in the plasma membrane of hen anterior pituitary and this binding component had properties of a receptor which has binding specificity to cCT, reversibility, saturable binding, high affinity and limited capacity. When anterior pituitary cells were incubated in vitro, cCT increased the maximal secretion of chicken ACTH stimulated by rhCRH. These results suggest that CT may act directly on the anterior pituitary via its receptor binding and enhances the ACTH secretion by CRH.