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Pinpointing the candidate region for muscular dystrophy in chickens with an abnormal muscle gene
Author(s) -
MATSUMOTO Hirokazu,
MARUSE Hideaki,
YOSHIZAWA Kanako,
SASAZAKI Shinji,
FUJIWARA Akira,
KIKUCHI Takeki,
ICHIHARA Nobutsune,
MUKAI Fumio,
MANNEN Hideyuki
Publication year - 2007
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/j.1740-0929.2007.00465.x
Subject(s) - muscular dystrophy , candidate gene , gene , genetics , haplotype , biology , skeletal muscle , genotype , anatomy
Muscular dystrophies, a group of inherited diseases with the progressive weakness and degeneration of skeletal muscle, contain genetically variable diseases. Though chicken muscular dystrophy with abnormal muscle ( AM ) has long been known, the gene responsible has not yet been identified. In this study, a resource family for AM was established with 487 F2 individuals and 22 gene markers, including microsatellite and insertion–deletion markers, were developed. The haplotypes were analyzed with these markers for the candidate region of GGA2q described in a previous study. The candidate region was successfully narrowed down to approximately 1Mbp. The region included seven functional genes predicted as the most likely AM candidates.