Premium
Functions of histone H2A variants
Author(s) -
LI Shaohua,
LIU Honglin
Publication year - 2006
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/j.1740-0929.2006.00385.x
Subject(s) - chromatin , histone h2a , nucleosome , histone , histone methylation , histone code , biology , genetics , dna replication , histone octamer , microbiology and biotechnology , dna , gene , gene expression , dna methylation
One way that cells alter their chromatin structure is by incorporating histone variants into their nucleosomes. Unlike canonical histones, which are deposited behind the replication fork during the S‐phase of cell division, the accumulation of histone variants is independent of DNA replication. However, among the histone variants, H2A variants play an important role in DNA replication, damage repair, recombination and gene expression. This paper provides a review of H2A histone variants and their functions, exchange in the chromatin and depositional modes by specific chaperones.