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Polymorphism and evolutionary profile of mitochondrial DNA control region inferred from the sequences of Pakistani goats
Author(s) -
SULTANA Saira,
MANNEN Hideyuki
Publication year - 2004
Publication title -
animal science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.606
H-Index - 38
eISSN - 1740-0929
pISSN - 1344-3941
DOI - 10.1111/j.1740-0929.2004.00190.x
Subject(s) - mitochondrial dna , lineage (genetic) , phylogenetic tree , mtdna control region , haplotype , biology , genetics , evolutionary biology , phylogenetics , block (permutation group theory) , genetic diversity , d loop , gene , genotype , population , demography , sociology , geometry , mathematics
Complete mitochondrial DNA (mtDNA) control region of 30 Pakistani domestic goats was sequenced to investigate the genetic diversity and organization. Twenty‐two new haplotypes were observed and all were classified into mt‐lineage A . Phylogenetic analysis revealed two distinct clusters in mt‐lineage A , A1 and A2 . A 17 bp deletion and a 76 bp insertion were detected in the L‐domain and observed 10 and one animals, respectively, in 232 Pakistani domestic goats. These remarkable deletion/insertion events would be useful to investigate mtDNA diversity within the highly divergent mt‐lineage A . In analysis of the control region feature, the caprine mtDNA was A/T rich as observed for other artiodactyls. Four conserved regions, Block A in the L domain, the C‐domain, Block B and CSB1 in the R domain, were defined as well as in the other species.