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Constant Strain Rate and Peri‐Implant Bone Modeling: An In Vivo Longitudinal Micro‐CT Analysis
Author(s) -
De Smet Els,
Jaecques Siegfried V. N.,
Wevers Martine,
Sloten Jos Vander,
Naert Ignace E.
Publication year - 2013
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/j.1708-8208.2011.00375.x
Subject(s) - in vivo , dentistry , implant , peri , strain (injury) , peri implantitis , constant (computer programming) , medicine , strain rate , biomedical engineering , materials science , surgery , computer science , anatomy , composite material , biology , microbiology and biotechnology , programming language
Background: Strain, frequency, loading time, and strain rate, among others, determine mechanical parameters in osteogenic loading. We showed a significant osteogenic effect on bone mass (BM) by daily peri‐implant loading at 1.600 µε.s −1 after 4 weeks. Purpose: To study the peri‐implant osteogenic effect of frequency and strain in the guinea pig tibia by in vivo longitudinal micro‐computed tomography (CT) analysis. Material and Methods: One week after implant installation in both hind limb tibiae, one implant was loaded daily for 10′ during 4 weeks, while the other served as control. Frequencies (3, 10, and 30 Hz) and strains varied alike in the three series to keep the strain rate constant at 1.600 µε.s −1 . In vivo micro‐CT scans were taken of both tibiae: 1 week after implantation but before loading (v1) and after 2 (v2) and 4 weeks (v3) of loading as well as postmortem (pm). BM (BM (%) bone‐occupied area fraction) was calculated as well as the difference between test and control sides (delta BM) Results: All implants ( n = 78) were clinically stable at 4 weeks. Significant increase in BM was measured between v1 and v2 ( p < .0001) and between v1 and v3 ( p < .0001). A significant positive effect of loading on delta BM was observed in the distal peri‐implant marrow 500 Region of Interest already 2 weeks after loading ( p = .01) and was significantly larger (11%) in series 1 compared with series 2 ( p = .006) and 3 ( p = .016). Conclusions: Within the constraints of constant loading time and strain rate, the effect of early implant loading on the peri‐implant bone is strongly dependent on strain and frequency. This cortical bone model has shown to be most sensitive for high force loading at low frequency.