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Origins and morphogenesis of colorectal neoplasms
Author(s) -
WONG WAIMAN,
GARCIA SERGIO B.,
WRIGHT NICHOLAS A.
Publication year - 1999
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1999.tb01590.x
Subject(s) - crypt , morphogenesis , carcinogenesis , biology , pathology , epithelium , colorectal cancer , mechanism (biology) , cancer research , medicine , cancer , genetics , endocrinology , philosophy , gene , epistemology
Gastrointestinal stem cells are considered pivotal in colonic carcinogenesis. There is evidence to suggest that early microadenomas in the colon are polyclonal in origin. Adenomas, once initiated, enlarge by the process of crypt fission. It is also the main mechanism by which neoplastic clones spread through the colorectal epithelium. Both concepts are important for our understanding of the early events in colonic carcinogenesis.