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HLA‐DR expression is a significant prognostic factor in laryngeal cancer
Author(s) -
SIKORSKA BEATA,
DANILEWICZ MARIAN,
WAGROWSKADANILEWICZ MALGORZATA
Publication year - 1999
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1999.tb01569.x
Subject(s) - malignancy , human leukocyte antigen , stage (stratigraphy) , laryngeal neoplasm , medicine , cancer , clinical significance , pathology , survival analysis , oncology , statistical significance , antigen , biology , immunology , paleontology
HLA‐DR antigen expression in tumour cells was investigated in 68 laryngeal carcinomas. The tissue sections were studied by a morphometric method using a computer image analysis system. Although the highest number of HLA‐DR‐positive cells was observed in the groups with the lowest clinical stage, these differences did not reach statistical significance. Analysis of survival showed a significantly different survival time of patients classified as HLA‐DR positive (10% and more HLA‐DR+tumour cells) compared to those classified as HLA‐DR negative. There were no significant differences in survival times between patients with glottic and extraglottic cancers, or between patients with various grades of histological malignancy.