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T‐cell activation and the dynamic world of rafts:
Author(s) -
Viola Antonella,
Lanzavecchia Antonio
Publication year - 1999
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1999.tb01450.x
Subject(s) - t cell receptor , microbiology and biotechnology , t cell , cytoskeleton , lipid raft , actin , actin cytoskeleton , cell , immunological synapse , cell membrane , receptor , cell signaling , chemistry , biology , signal transduction , immunology , immune system , biochemistry
Recent evidence, indicates that T‐cell receptor (TCR) triggering and T‐cell activation are dynamic processes that involve various aspects of T‐cell organization. In addition to the interaction between the TCR molecule and its ligand, T‐cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen‐presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.