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Expression of group II phospholipase A2 in Paneth cells of an adenoma of the rectum
Author(s) -
NEVALAINEN TIMO J.,
HAAPANEN TIMO J.,
RAJALA PERTTI,
EKFORS TAUNO
Publication year - 1998
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1998.tb00224.x
Subject(s) - rectum , in situ hybridization , phospholipase a2 , immunohistochemistry , biology , basal (medicine) , adenoma , pathology , lysozyme , microbiology and biotechnology , enzyme , medicine , endocrinology , messenger rna , biochemistry , immunology , gene , insulin
A case of tubulovillous adenoma in the rectum of a 51‐year‐old man is presented. The tumour contained numerous Paneth cells which formed well‐developed glands in the basal areas. Group II phospholipase A2 and lysozyme were found in the tumour cells by immunohistochemistry. mRNA of group II phospholipase A2 was localized in the tumour cells by in situ hybridization. It was concluded that a considerable part of this rare type of tumour consisted of Paneth cells which were capable of synthesizing group II phospholipase A2.