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S‐100 protein‐positive dendritic cells in follicular lesions of the thyroid
Author(s) -
HIROKAWA MITSUYOSHI,
SHIMIZU MICHIO,
MANABE TOSHIAKI,
SONOO HIROSHI,
HARADA TANEKAZU
Publication year - 1998
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1998.tb00215.x
Subject(s) - follicular phase , follicular dendritic cells , pathology , adenoma , stroma , thyroid , immunohistochemistry , medicine , follicular carcinoma , follicular cell , thyroid carcinoma , immunology , papillary carcinoma , antigen presenting cell , immune system , t cell
Little is known about the role of S‐100 protein‐positive dendritic cells in follicular lesions of the thyroid. In 36 cases of adenomatous goitre, 18 cases of follicular adenoma, and 7 cases of follicular carcinoma, we investigated the incidence and distribution of S‐100 protein‐positive dendritic cells using immunohistochemical staining. Four cases (10.5%) of adenomatous goitre, five cases (31.3%) of follicular adenoma, and 6 cases (85.7%) of follicular carcinoma contained S‐100 protein‐positive dendritic cells in the subcapsular area and/or the hyalinized stroma. Dendritic cells in the subcapsular area were observed only in lesions with thick capsules and not those with thin capsules. In most cases of follicular carcinoma, ++ to +++ of the dendritic cells was seen together with a few lymphocytes and fibroblasts in the subcapsular areas. In contrast, cases of adenomatous goitre and follicular adenoma showed only a few dendritic cells without any inflammatory cells. Dendritic cells in follicular thyroid lesions may play some role in capsular formation or may be a secondary phenomenon due to capsular formation.