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T‐cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease
Author(s) -
BREGENHOLT SØOREN,
DELBRO DICK,
CLAESSON MOGENS H.
Publication year - 1997
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1997.tb05068.x
Subject(s) - inflammatory bowel disease , adoptive cell transfer , immunology , cytokine , t cell receptor , t cell , animal model , gene transfer , disease , medicine , biology , gene , immune system , pathology , genetics , endocrinology
Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease‐inductive and ‐protective cell types, subsets and cytokines, for example CD4+ T cells, IFNΛ, IL‐12, IL‐2, IL‐10 and TGFβ. Furthermore, these recent IBD models make it possible to examine various chemo‐ and immunotherapeutic approaches. This review focuses on IBD development in adoptive T‐cell transfer models and in gene‐deleted mice.